{ "id": 4837, "date": "2020-11-19T22:48:56", "date_gmt": "2020-11-19T20:48:56", "guid": { "rendered": "http:\/\/www.vet.uth.gr\/?post_type=project&p=4837" }, "modified": "2026-02-14T16:00:54", "modified_gmt": "2026-02-14T14:00:54", "slug": "%ce%ba%ce%bf%ce%bd%cf%84%ce%bf%cf%80%ce%af%ce%b4%ce%b7%cf%82-%ce%b3%ce%b5%cf%8e%cf%81%ce%b3%ce%b9%ce%bf%cf%82", "status": "publish", "type": "project", "link": "https:\/\/www.vet.uth.gr\/en\/?project=%ce%ba%ce%bf%ce%bd%cf%84%ce%bf%cf%80%ce%af%ce%b4%ce%b7%cf%82-%ce%b3%ce%b5%cf%8e%cf%81%ce%b3%ce%b9%ce%bf%cf%82", "title": { "rendered": "Kontopidis George" }, "content": { "rendered": "

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”http:\/\/www.vet.uth.gr\/wp-content\/uploads\/2020\/01\/Kontopidis-e1577979502524.jpg” title_text=”Kontopidis” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” content__hover_enabled=”on|desktop” content__hover=”<\/p>\n

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<\/i>Email: gkontopidis@uth.gr<\/a><\/div>\n
<\/i>Phone: +30 24410 66017<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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Contact with students: <\/b>\u03a4\u03b5\u03c4\u03ac\u03c1\u03c4\u03b7 09:00 – 10:00 \u03a0\u03ad\u03bc\u03c0\u03c4\u03b7 09:00 – 10:00<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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<\/i>Email: gkontopidis@uth.gr<\/a><\/div>\n
<\/i>Phone: +30 24410 66017<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\u00a0Contact with students: <\/b>\u03a4\u03b5\u03c4\u03ac\u03c1\u03c4\u03b7 09:00 – 10:00 \u03a0\u03ad\u03bc\u03c0\u03c4\u03b7 09:00 – 10:00<\/p>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

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George Kontopidis<\/b><\/h3>\n

Professor<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n
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Biochemistry<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Research interests<\/strong><\/h3>\n
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Functional & Structure Biochemistry: Protein chemistry, Drug design, assay development, drug delivery-liposome research. The current focus is B-Raf kinase and protein targets for therapy of Rheumatoid Arthritis.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Curriculum vitae<\/strong><\/h3>\n
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EDUCATION\n1986-1991 University of Ioannina, Greece, Department of Chemistry, Bachelor in Chemistry\n1994-95 University of Strathclyde, UK, Department of Bioscience and Biotechnology, Master of Philosophy in Biotechnology\n1995-98 University of Edinburgh, UK, Department of Biochemistry, Doctor of Philosophy in Structural Biology<\/p>\n

RESEARCH FIELD OF WORK
Functional & Structure Biochemistry: Protein chemistry, Drug design, assay development, drug delivery-liposome\nresearch.<\/p>\n

WORKING EXPERIENCE\n2016-Professor of Biochemistry, Head BL, VT, UT\nApr 2018-Sep 2018 Visiting Professor, Inst. Biology, Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, Greece\nOct 2017-Mar 2018 Visiting Professor, College of Pharmacy, Universityof South Carolina, USA\n2010-16 Associate Professor, Head BL, VT, UT\n2006-10 Assistant Professor, Veterinary Faculty, University of Thessaly<\/p>\n

1999-01 Post-doctoral Research Fellow, ICMB, University of Edinburgh, Edinburgh U.K.\n2001-04 Scientist Cyclacel Ltd, James Lindsay Place, Dundee U.K.\n2001-06 Research Scientist Cyclacel Ltd, James Lindsay Place, Dundee U.K.<\/p>\n

Undergraduate cources and lectures:\nCourse Instructor\/Leader, \u201cGeneral Principles of Biochemistry\u201d, 2015-17, 2017-20\nCourse Instructor\/Leader, \u201cBiochemistry of Metabolism\u201d, 2015-17, 2017-20\nCourse Instructor\/Leader, \u201cCellular and Molecular Biology\u201d, 2018-19\nCourse Instructor\/Leader, \u201cPrinciples of Chemistry for Veterinary Science\u201d, 2006-15\nCourse Instructor\/Leader, \u201cBiochemistry\u201d, 2006-15\nCourse Instructor, \u201cPrinciples of Physics for Veterinary Science\u201d, 2006-14\nCourse Leader \u201cAnimal Nutrition practicals\u201d, 2012-14<\/p>\n

\u039c\u03b5\u03c4\u03b1\u03c0\u03c4\u03c5\u03c7\u03b9\u03b1\u03ba\u03ae \u0394\u03b9\u03b4\u03b1\u03c3\u03ba\u03b1\u03bb\u03af\u03b1
\u0392\u03b9\u03bf-\u0395\u03c0\u03b9\u03c7\u03b5\u03b9\u03c1\u03b5\u03af\u03bd \u03a4\u03bc\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u0392\u03b9\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1\u03c2 & \u0392\u03b9\u03bf\u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03a0\u0398 \u03ba\u03b1\u03b9 \u0395\u03b8\u03bd\u03b9\u03ba\u03cc \u038a\u03b4\u03c1\u03c5\u03bc\u03b1 \u0395\u03c1\u03b5\u03c5\u03bd\u03ce\u03bd,
\u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c7\u03b5\u03b9\u03c1\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03bd\u03ac\u03b4\u03c9\u03bd (4 \u03b1\u03ba\u03b1\u03b4\u03b7\u03bc\u03b1\u03ca\u03ba\u03ac \u03ad\u03c4\u03b7)<\/p>\n

PhD Supervision\n\u2022 supervisor M. Rovoli, \u201cBinding of lipophilic vitamins in protein and micelle and their use as vehicle to increase\nbioavailability\u201d, Veterinary Department of Thessaly University (March 2015)\n\u2022supervisor A. Mettou, \u201cLead discovery molecules for TNF \u03ba\u03b1\u03b9 RANKL target proteins for Rheumatoid Arthritis\u201d,\nVeterinary Department of Thessaly University (September 2017)<\/p>\n

Full curriculum vitae<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Courses<\/strong><\/h3>\n
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    General Principles of Biochemistry<\/div>\n<\/li>\n
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    Biochemistry of Metabolism<\/div>\n<\/li>\n
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    Principles of Chemistry for Veterinary Science<\/div>\n<\/li>\n
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    Biochemistry<\/div>\n<\/li>\n
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    Principles of Physics for Veterinary Science<\/div>\n<\/li>\n
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    Animal Nutrition practicals<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
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    Selected Publications<\/strong><\/h3>\n
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    1) Invited review: \u03b2-lactoglobulin: binding properties, structure, and function, G Kontopidis, C Holt, L Sawyer, Journal of dairy science 2004, 87 (4), 785-796<\/p>\n

    2) Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design, G Kontopidis, SY Wu, DI Zheleva, P Taylor, C McInnes, DP Lane, \u2026, Proceedings of the National Academy of Sciences, 2005, 102 (6), 1871-1876<\/p>\n

    3) Quantification of the effects of ionic strength, viscosity, and hydrophobicity on protein\u2013ligand binding affinity CP Papaneophytou, AI Grigoroudis, C McInnes, G Kontopidis ACS Medicinal Chemistry Letters, 2014, 5 (8), 931-936<\/p>\n

    4) In vitro and in vivo assessment of vitamin A encapsulation in a liposome\u2013protein delivery system M Rovoli, I Pappas, S Lalas, O Gortzi, G Kontopidis, Journal of liposome research, 2019, 29 (2), 142-152<\/p>\n

    5) Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-\u03baB Ligand with a Superior Therapeutic Index V Rinotas, A Papakyriakou, F Violitzi, C Papaneophytou, MD Ouzouni, Journal of Medicinal Chemistry, 2020, 63 (20), 12043-12059<\/p>\n

    6) Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3\u2500Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds,L L\u00e1z\u00e1r, AS Tsagkarakou, G Stravodimos, G Kontopidis, H Leffler, UJ Nilsson, L Soms\u00e1k, DD Leonidas,Journal of Medicinal Chemistry, 2023, 66, 12420-12431<\/p>\n

    7) Comparative analysis of biochemical and cellular assay conditions and the need for a buffer that mimics cytoplasmic environments. G Kontopidis & IS Patergiannakis Molecules, 2025, 30, 3630<\/p>\n<\/div>\n<\/div>\n

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    [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>", "protected": false }, "excerpt": { "rendered": "

    Email: gkontopidis@uth.gr \u03a4\u03b7\u03bb\u03ad\u03c6\u03c9\u03bd\u03bf: +30 24410 66017 \u00a0\u038f\u03c1\u03b5\u03c2 \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c6\u03bf\u03b9\u03c4\u03b7\u03c4\u03ad\u03c2: \u03a4\u03b5\u03c4\u03ac\u03c1\u03c4\u03b7 09:00 – 10:00 \u03a0\u03ad\u03bc\u03c0\u03c4\u03b7 09:00 – 10:00 \u0393\u03b5\u03ce\u03c1\u03b3\u03b9\u03bf\u03c2 \u039a\u03bf\u03bd\u03c4\u03bf\u03c0\u03af\u03b4\u03b7\u03c2 \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u0392\u03b9\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1 \u00a0 \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1 \u039b\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae & \u03b4\u03bf\u03bc\u03ae \u0392\u03b9\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1: \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03af\u03b1, \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd, \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03bc\u03b5\u03b8\u03cc\u03b4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b5\u03ba\u03bb\u03bf\u03b2\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd-\u03bb\u03b9\u03c0\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03b1. \u0397 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03b5\u03c0\u03b9\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd B-Raf \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 (TNF \u03ba\u03b1\u03b9 RANKL). \u00a0 […]<\/p>", "protected": false }, "author": 1, "featured_media": 879, "comment_status": "open", "ping_status": "closed", "template": "", "meta": { "_et_pb_use_builder": "on", "_et_pb_old_content": "", "_et_gb_content_width": "", "footnotes": "" }, "project_category": [ 16 ], "project_tag": [], "class_list": [ "post-4837", "project", "type-project", "status-publish", "has-post-thumbnail", "hentry", "project_category-personal-websites" ], "_links": { "self": [ { "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=\/wp\/v2\/project\/4837", "targetHints": { "allow": [ "GET" ] } } ], "collection": [ { "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=\/wp\/v2\/project" } ], "about": [ { "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=\/wp\/v2\/types\/project" } ], "author": [ { "embeddable": true, "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=\/wp\/v2\/users\/1" } ], "replies": [ { "embeddable": true, "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4837" } ], "version-history": [ { "count": 20, "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=\/wp\/v2\/project\/4837\/revisions" } ], "predecessor-version": [ { "id": 11846, "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=\/wp\/v2\/project\/4837\/revisions\/11846" } ], "wp:featuredmedia": [ { "embeddable": true, "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=\/wp\/v2\/media\/879" } ], "wp:attachment": [ { "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4837" } ], "wp:term": [ { "taxonomy": "project_category", "embeddable": true, "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fproject_category&post=4837" }, { "taxonomy": "project_tag", "embeddable": true, "href": "https:\/\/www.vet.uth.gr\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fproject_tag&post=4837" } ], "curies": [ { "name": "wp", "href": "https:\/\/api.w.org\/{rel}", "templated": true } ] } }