Phone: +30 24410 66017

 Contact with students: Τετάρτη 09:00 – 10:00 Πέμπτη 09:00 – 10:00

George Kontopidis




Research interests

Functional & Structure Biochemistry: Protein chemistry, Drug design, assay development, drug delivery-liposome research. The current focus is B-Raf kinase and protein targets for therapy of Rheumatoid Arthritis.


Curriculum vitae

EDUCATION 1986-1991 University of Ioannina, Greece, Department of Chemistry, Bachelor in Chemistry 1994-95 University of Strathclyde, UK, Department of Bioscience and Biotechnology, Master of Philosophy in Biotechnology 1995-98 University of Edinburgh, UK, Department of Biochemistry, Doctor of Philosophy in Structural Biology

Functional & Structure Biochemistry: Protein chemistry, Drug design, assay development, drug delivery-liposome research.

WORKING EXPERIENCE 2016-Professor of Biochemistry, Head BL, VT, UT Apr 2018-Sep 2018 Visiting Professor, Inst. Biology, Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, Greece Oct 2017-Mar 2018 Visiting Professor, College of Pharmacy, Universityof South Carolina, USA 2010-16 Associate Professor, Head BL, VT, UT 2006-10 Assistant Professor, Veterinary Faculty, University of Thessaly

1999-01 Post-doctoral Research Fellow, ICMB, University of Edinburgh, Edinburgh U.K. 2001-04 Scientist Cyclacel Ltd, James Lindsay Place, Dundee U.K. 2001-06 Research Scientist Cyclacel Ltd, James Lindsay Place, Dundee U.K.

Undergraduate cources and lectures: Course Instructor/Leader, “General Principles of Biochemistry”, 2015-17, 2017-20 Course Instructor/Leader, “Biochemistry of Metabolism”, 2015-17, 2017-20 Course Instructor/Leader, “Cellular and Molecular Biology”, 2018-19 Course Instructor/Leader, “Principles of Chemistry for Veterinary Science”, 2006-15 Course Instructor/Leader, “Biochemistry”, 2006-15 Course Instructor, “Principles of Physics for Veterinary Science”, 2006-14 Course Leader “Animal Nutrition practicals”, 2012-14

Μεταπτυχιακή Διδασκαλία
Βιο-Επιχειρείν Τμήματος Βιοχημείας & Βιοτεχνολογίας του ΠΘ και Εθνικό Ίδρυμα Ερευνών,
σχεδιασμός και υλοποίηση επιχειρηματικών μονάδων (4 ακαδημαϊκά έτη)

PhD Supervision • supervisor M. Rovoli, “Binding of lipophilic vitamins in protein and micelle and their use as vehicle to increase bioavailability”, Veterinary Department of Thessaly University (March 2015) •supervisor A. Mettou, “Lead discovery molecules for TNF και RANKL target proteins for Rheumatoid Arthritis”, Veterinary Department of Thessaly University (September 2017)

Full curriculum vitae



  • General Principles of Biochemistry
  • Biochemistry of Metabolism
  • Principles of Chemistry for Veterinary Science
  • Biochemistry
  • Principles of Physics for Veterinary Science
  • Animal Nutrition practicals

Selected Publications

1) Invited review: β-lactoglobulin: binding properties, structure, and function, G Kontopidis, C Holt, L Sawyer, Journal of dairy science 2004, 87 (4), 785-796

2) Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design, G Kontopidis, SY Wu, DI Zheleva, P Taylor, C McInnes, DP Lane, …, Proceedings of the National Academy of Sciences, 2005, 102 (6), 1871-1876

3) Quantification of the effects of ionic strength, viscosity, and hydrophobicity on protein–ligand binding affinity CP Papaneophytou, AI Grigoroudis, C McInnes, G Kontopidis ACS Medicinal Chemistry Letters, 2014, 5 (8), 931-936

4) In vitro and in vivo assessment of vitamin A encapsulation in a liposome–protein delivery system M Rovoli, I Pappas, S Lalas, O Gortzi, G Kontopidis, Journal of liposome research, 2019,  29 (2), 142-152

5) Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index V Rinotas, A Papakyriakou, F Violitzi, C Papaneophytou, MD Ouzouni, Journal of Medicinal Chemistry, 2020, 63 (20), 12043-12059